Biologic Therapies for Rheumatoid Arthritis: What Patients Should Know

Rheumatoid arthritis (RA) is an autoimmune condition in which the immune system mistakenly attacks the joints, causing inflammation, pain, and — over time — permanent joint damage. For patients with moderate to severe RA who haven't responded adequately to traditional treatments like methotrexate, biologic therapies have become the standard of care and have truly transformed outcomes.

Our pharmacists are experienced in biologic therapies for RA and will guide you through everything — from injection technique to lab monitoring to managing side effects — every step of the way.

What are biologics?

Unlike traditional small-molecule drugs, biologics are large, complex molecules derived from living cells. They target specific components of the immune system — such as TNF-alpha, IL-6, or B cells — that drive RA inflammation. Because they're so targeted, biologics can be highly effective while having a more favorable side effect profile than broad immunosuppressants.

Common biologic medications for RA

Several biologics are currently FDA-approved for RA, including adalimumab (Humira), etanercept (Enbrel), infliximab (Remicade), tocilizumab (Actemra), abatacept (Orencia), and JAK inhibitors like upadacitinib (Rinvoq). Your rheumatologist will recommend the best option based on your disease severity, prior treatment history, and other health factors.

Biosimilars: equally effective, lower cost

Biosimilars — FDA-approved lower-cost alternatives to original biologics — are now widely available for most RA medications and have been shown in clinical studies to be equally effective and safe. Biosimilar adoption has grown significantly in 2025 and 2026 as both payers and providers recognize their value. Ask your rheumatologist whether a biosimilar is appropriate for your situation.

Storage, administration, and what to expect

Our pharmacists walk you through injection technique and what to expect from biologic therapy.

Most RA biologics are administered by self-injection (weekly or biweekly) and require refrigeration at 36–46°F. They should never be frozen. Our pharmacists will walk you through the injection technique step by step, review proper storage, and go over what to do if you miss a dose or experience a reaction at the injection site.

Monitoring while on biologic therapy

Before starting a biologic, your rheumatologist will screen you for tuberculosis and hepatitis B, since these medications can increase the risk of certain infections. During treatment, periodic lab work is required. Our team coordinates with your physician to ensure all monitoring is completed on schedule, so your therapy stays safe and effective long-term.